Prior to the manufacture of tablets do extract raw materials testing which includes the determination of the levels of ash, determination of microbial impurities, testing the determination of aflatoxin levels of impurities, the determination of the levels of pesticide residues, the determination of the level of heavy metal impurities. This research aims to make the tablet dosage of Caulis extract with gelatin Binder and polivenilpirolidon materials that meet the requirements of the physical quality of a tablet that is acceptable. The entire plant (roots, stems, and leaves) has a bitter taste that can be used as a traditional medicine as Plasmodium. Thomson is a wild plant & in the Woods, fields or planted page near the fence, and the usual planted as medicinal plants. Penuntun Ilmu Kosmetik Medik.Brotowali (Tinospora crispa (L.) Hook. Keuntungan dan Kerugian Patch Test (Uji Tempel) Dalam Upaya Menegakkan Diagnosa Penyakit Kulit Akibat Kerja (Occupational Dermatosis). The Association of Food and Drug Officials of the United States, Bureau of Food and Drugs, Austin, TX dan Tedjo Y., 2015, Evaluasi Uji Iritasi dan Uji Sifat Fisik Sediaan Emulgel Minyak Atsiri Bunga Cengkeh (Syzigium aromaticum), Pharmaciana, Vol 5 No 2, Fakultas Farmasi, Universitas Ahmad Dahlan, Yogyakartaĭraize, J.H., 1959, Dermal Toxicity, Pages 46-59 in Appraisal of the Safety of Chemicals in Food, Drugs and Cosmetics. Pengantar Bentuk Sediaan Farmasi Edisi 4. Keywords : binahong leave, gelling agent, irritation test.Īnsel, H. Of the three gel preparation formulas, the score of degree of irritation was 1, 1 and 1.67, which means slight irritation (0.41-1.9). Each area observed skin reactions that occur and scored 0 to 4 depending on the severity of skin reactions produced. Observations were made after 24, 48 and 72 hours after administration of the test material. The irritant samples were smeared and then covered with sterile gauze and glued with plaster. The irritation test was performed by Draize method on three New Zealand male rabbits who had shaved the back part 24 hours prior to treatment. The aim of this research is to find out whether gel preparation of the active fraction of ethanol extract of binahong lea ve with combination of gelling agent Hydroxy Propyl Methyl Cellulose (HPMC) and carbopol can cause irritation on rabbit skin. In Material Safety Data Sheet states that Hydroxy Propyl Methyl Cellulose (HPMC) and Carbopol can cause skin irritation problems. Skin irritation test is an important part of the pharmaceutical preparation procedures. Gelling agent is the main ingredient in gel preparation. Gel is a pharmaceutical preparation with good penetration power and long contact time with skin so it can overcome the problem of acne.
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